In 2010 Focusrite partnered with Audinate to create the RedNet PCIe card, bringing high channel counts and low latency between Windows and Mac computers and Dante networks.
The card in question was built on Gen 1 PCIe technology. In the intervening decade there have been numerous updates to the PCIe spec, with the unfortunate result being that there’s an incompatibility with some modern motherboards that don’t seem to fully support older PCIe devices. This is a hardware-level incompatibility, there is no way to work around it in the associated firmware/driver.
With a view to being as transparent as possible, we can therefore confirm that we cannot support and do not recommend attempting to use RedNet PCIe/PCIeR on AMD Ryzen-based systems specifically.
We have previously stated this but also to confirm: RedNet PCIe and RedNet PCIeR will not be compatible with Apple Silicon systems (also known as "M1”, “M2” etc).
While we cannot comment on potential future product development, we are of course aware of the continued desire for high channel count, low-latency, Dante-based recording systems beyond the current projected lifetime of the RedNet PCIe/PCIeR card.